反应详情

6-Bromo-7-chloro-2-(3,5-dimethylphenyl)quinoline (5.2 g, 15.0 mmol), isobutylboronic acid (6.12 g, 60.0 mmol), dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine (0.99 g, 2.4 mmol), Pd2(dba)3 (0.549 g, 0.60 mmol), potassium phosphate monohydrate (34.5 g, 150 mmol) and 2 mL of water were mixed in 240 mL of toluene. The system was degassed with nitrogen for 20 minutes and refluxed overnight. After cooling to room temperature, the reaction mixture was filtered through a Celite® plug and eluted with dichloromethane. The product was purified by column chromatography, eluting with 2:1 (v/v) hexanes:DCM, to give 2-(3,5-dimethylphenyl)-6,7-diisobutylquinoline (3.43 g, 66%).

1. customThe system was degassed with nitrogen for 20 minutes
2. temperaturerefluxed overnight
3. filtrationthe reaction mixture was filtered through a Celite® plug
4. washeluted with dichloromethane
5. customThe product was purified by column chromatography
6. washeluting with 2:1 (v/v) hexanes