Methanesulfonic Acid → HCID 90229562, compound

HRID 1505814Notes

Reaction equation

HRID 1505814 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[C:8]([CH3:41])=[C:9]([NH:13][C:14]([C:16]2[C:24]3[N:23]=[C:22]([CH2:25][O:26][CH3:27])[NH:21][C:20]=3[CH:19]=[C:18]([NH:28][C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:40])([F:39])[F:38])=[O:30])[CH:17]=2)=[O:15])[CH:10]=[CH:11][CH:12]=1>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[C:8]([CH3:41])=[C:9]([NH:13][C:14]([C:16]2[C:24]3[N:23]=[C:22]([CH2:25][O:26][CH3:27])[NH:21][C:20]=3[CH:19]=[C:18]([NH:28][C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:38])([F:39])[F:40])=[O:30])[CH:17]=2)=[O:15])[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 712674451422203-86-8

Product 1

HCID 90229562HCID 90229562, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanesulfonic acid (1 Eq) was added to a suspension of N-(3-chloro-2-methylphenyl)-2-(methoxymethyl)-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxamide (250 mg) (obtained in Example 11) in MeOH (2 ml). After stirring for 30 minutes at room temperature, MeOH was removed under reduced pressure to obtain the titled compound as white powder.

Workup

  1. customMeOH was removed under reduced pressure

Sources & evidence

ORD record
ord-039b0147477b427085044e1124acce8b
Source dataset
uspto-grants-2015_12
Patent number
US09216968B2

Reaction notes

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