Hydrogen Bromide → HCID 67203533, compound

HRID 1505952Notes

Reaction equation

C(C([CH2:7][CH2:8][NH:9][C:10]1[CH:32]=[N:31][C:13]2[N:14](COCC[Si](C)(C)C)[C:15]3[CH:20]=[N:19][C:18]([C:21]#[N:22])=[CH:17][C:16]=3[C:12]=2[CH:11]=1)=O)(C)(C)C.Br.[OH-].[Na+].Cl>O1CCOCC1>[CH2:8]([NH:9][C:10]1[CH:32]=[N:31][C:13]2[NH:14][C:15]3[CH:20]=[N:19][C:18]([C:21]#[N:22])=[CH:17][C:16]=3[C:12]=2[CH:11]=1)[CH3:7]

Participants

Conditions

Temperature: 75 °C

Procedure

A solution of 3-(tert-butylcarbonyl)ethylamino-9-(2-trimethylsilanyl-ethoxymethyl)-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile (161 mg, 0.345 mmol) in 1,4-dioxane (500 μL) was treated with 48% aqueous hydrobromic acid (500 μL) and heated at 75° C. for 10 min. The cooled reaction mixture was basified to pH 12 with 6N aqueous sodium hydroxide solution and then adjusted to pH 7-9 with dropwise addition of 1N hydrochloric acid. The solid was collected via centrifugation, the aqueous supernate discarded, and the solid dissolved in 1-2 mL of DMSO and purified by preparative HPLC (5-85% MeCN in water (0.1% NH4OH) over 30 min, 35 mL/min) to afford the title compound as a yellow solid (22 mg, 26%). 1H NMR (DMSO-D6, 500 MHz): 8.89 (d, J=1.0 Hz, 1H), 8.78 (d, J=0.9 Hz, 1H), 8.22 (d, J=2.7 Hz, 1H), 7.78 (d, J=2.7 Hz, 1H), 5.76 (t, J=5.5 Hz, 1H), 3.20-3.07 (m, 2H), 1.25 (t, J=7.1 Hz, 3H). LCMS (Method E): RT=2.69 min, M+H+=238.1.

Workup

customThe cooled reaction mixture
customThe solid was collected via centrifugation
dissolutionthe solid dissolved in 1-2 mL of DMSO
custompurified by preparative HPLC (5-85% MeCN in water (0.1% NH4OH) over 30 min, 35 mL/min)

Sources & evidence

ORD record: ord-2cc7efe0c81246daaf6ee1b57af09e5f
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09216980B2

Reaction notes

Loading…