m-Chloroperbenzoic acid → HCID 178526232, compound

HRID 1506223Notes

Reaction equation

HRID 1506223 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[Br:12][C:13]1[CH:14]=[C:15]2[N:21]=[CH:20][NH:19][C:16]2=[N:17][CH:18]=1>C(OCC)(=O)C>[Br:12][C:13]1[CH:14]=[C:15]2[N:21]=[CH:20][NH:19][C:16]2=[N+:17]([O-:9])[CH:18]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 9115786-Bromo-4H-imidazo[4,5-b]pyridine

Product 1

HCID 178526232HCID 178526232, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

m-Chloroperbenzoic acid (25 wt % water content, 2.77 g, 12.0 mmol) was gradually added dropwise to 6-bromo-3H-imidazo[4,5-b]pyridine (1.58 mg, 7.98 mmol) in ethyl acetate (15 mL), and the reaction mixture was stirred at room temperature for one day. The precipitated solid was collected by filtration and washed with ethyl acetate and diethyl ether and dried under reduced pressure to give the title compound as a pale yellow solid (1.67 g, yield 98%).

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with ethyl acetate and diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-86d93005289b43f39430e39ef5af3d7b
Source dataset
uspto-grants-2015_12
Patent number
US09216999B2

Reaction notes

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