反应详情

A mixture of (Z)—N-hydroxybenzimidoyl cyanide (Preparation 103A, 8 g, 55.1 mmol) and 4-methylbenzene-1-sulfonyl chloride (10.51 g, 55.1 mmol) in toluene (70 mL) was heated to reflux. After refluxing for 2 h, the reaction was cooled, diluted with EtOAc (100 mL) and washed with water (50 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated to yield (Z)—N-(tosyloxy)benzimidoyl cyanide (10 g, 33.3 mmol, 60.4% yield) as a light yellow solid.

1. temperaturewas heated to reflux
2. temperatureAfter refluxing for 2 h
3. temperaturethe reaction was cooled
4. washwashed with water (50 mL) and brine (50 mL)
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. concentrationconcentrated