Tributylvinyltin → HCID 67169434, compound

HRID 1506564Notes

Reaction equation

FC(F)(F)S(O[C:7]1[CH:28]=[CH:27][C:10]2[C:11]3[CH:12]=[N:13][N:14]([C:18]4[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH3:26])=[CH:20][CH:19]=4)[C:15]=3[CH2:16][CH2:17][C:9]=2[CH:8]=1)(=O)=O.[CH2:31]([Sn](CCCC)(CCCC)C=C)[CH2:32]CC.[Cl-].[Li+]>O1CCOCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH2:24]([C:21]1[CH:22]=[CH:23][C:18]([N:14]2[C:15]3[CH2:16][CH2:17][C:9]4[CH:8]=[C:7]([CH:31]=[CH2:32])[CH:28]=[CH:27][C:10]=4[C:11]=3[CH:12]=[N:13]2)=[CH:19][CH:20]=1)[CH2:25][CH3:26]

Participants

Conditions

Temperature: 100 °C

Procedure

To 3-(4-propylphenyl)-4,5-dihydro-3H-benzo[e]indazol-7-yl trifluoromethanesulfonate (Preparation 136D, 240 mg, 0.550 mmol) in dioxane was sequentially added tributyl(vinyl)stannane (0.178 mL, 0.605 mmol), lithium chloride (69.9 mg, 1.650 mmol) and tetrakis(triphenylphosphine)palladium(0) (38.1 mg, 0.033 mmol). Contents were purged with nitrogen gas for 5 min. and heated at 100° C. for 16 h.

Workup

customContents were purged with nitrogen gas for 5 min.

Sources & evidence

ORD record: ord-51bb6211c9b54ca7953f4a063d309e00
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09216972B2

Reaction notes

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