反应详情

To a solution of 9B (crude product) and DIPEA (1.5 mL, 8.4 mmol) in dichloromethane (10 mL), methanesulfonic anhydride (1.17, 6.7 mmol) was added to the mixture. Then it was stirred for overnight. The organic layer was washed with brine twice. The organic layer was dried with Na2SO4, filtered and concentrated. The crude product was purified by flash column (Rf: 0.6, 15% EtOAc/Hexanes) to provide the desired product. MS (m/z) 171 [M+H]+.

1. washThe organic layer was washed with brine twice
2. dry with materialThe organic layer was dried with Na2SO4
3. filtrationfiltered
4. concentrationconcentrated
5. customThe crude product was purified by flash column (Rf: 0.6, 15% EtOAc/Hexanes)