反应详情

To a suspension of 10D and hydroxylamine hydrochloride (420 mg, 6 mmol) in ethanol (5 mL), sodium hydroxide (480 mg, 12 mmol) was added. It was refluxed for two hours. The reaction was acidified with 1 N hydrochloride and extracted with ethyl acetate (50 mL twice). The organic layer was dried with Na2SO4, filtered and concentrated. The crude product was purified by flash column) to provide the desired product. MS (m/z) 307 [M+H]+.

1. additionwas added
2. temperatureIt was refluxed for two hours
3. extractionextracted with ethyl acetate (50 mL twice)
4. dry with materialThe organic layer was dried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThe crude product was purified by flash column)