Ethanolamine → Oleoylethanolamide

HRID 1506729ノート

反応式

HRID 1506729 の反応式
[C:1]([OH:20])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:21]([CH2:23][NH2:24])[OH:22].O>CCCCCC>[C:1]([NH:24][CH2:23][CH2:21][OH:22])(=[O:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

参加物

5

反応物 3

HCID 700EthanolamineHCID 962WaterHCID 445639Oleic Acid

生成物 1

HCID 5283454Oleoylethanolamide

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

In an exemplary embodiment, 1 mmol oleic acid was reacted with 1 mmol ethanolamine in 1.5 mL hexane at 65° C. for 3 hours in the presence 30% lipase and 10 μL water. N-oleoyl ethanolamine with 96.6% purity was obtained and all oleic acid was consumed. In another exemplary embodiment, when the synthesis was conducted on a large scale (50 mmol of each of the reactants), the purity of N-oleoyl ethanolamine after crystallization purification was 96.1%. More examples of reacting the alkanolamine and the fatty acid to prepare the high-purity fatty acid N-acylalkanolamine in a high yield are described in Examples 9-18.

出典と根拠

ORDレコード
ord-188c955b7a494963abaf2054fb0d2e2f
出典データセット
uspto-grants-2015_12
特許番号
US09221747B2

反応ノート

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