Hydrochloric Acid → HCID 86720060, compound

HRID 1506764Notes

Reaction equation

HRID 1506764 reaction equation
[CH:1]1([N:4]([CH2:20][CH3:21])[CH2:5][CH2:6][CH2:7][CH2:8][NH:9]C(=O)OCC2C=CC=CC=2)[CH2:3][CH2:2]1.[ClH:22]>>[ClH:22].[CH:1]1([N:4]([CH2:20][CH3:21])[CH2:5][CH2:6][CH2:7][CH2:8][NH2:9])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70983743HCID 70983743, compound

Product 1

HCID 86720060HCID 86720060, compound

Conditions

Temperature
22.5 °C

Procedure

The mixture of benzyl 4-(cyclopropyl(ethyl)amino)butylcarbamate (Step 1) in HCl (6 N) was heated to reflux for 1 hour and cooled to 20-25° C. The reaction mixture was concentrated, and the residue was dried under reduced pressure to give N1-cyclopropyl-N1-ethylbutane-1,4-diamine HCl salt.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. concentrationThe reaction mixture was concentrated
  4. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-f112d18139d249e2944abb7e67a4c7bd
Source dataset
uspto-grants-2015_12
Patent number
US09221760B2

Reaction notes

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