反应详情

温度

100 °C

A solution of the sub-title product of step (iii) (94 g) dissolved in dioxane (700 mL) was treated with 3-methylazetidine-1-sulfonamide (Intermediate B) (42.5 g), potassium carbonate (65.1 g), dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (11.2 g) and tris(dibenzylideneacetone)dipalladium(0) (10.8 g) under nitrogen. The resulting mixture was stirred at 100° C. for 60 minutes. The reaction mixture was diluted with water (500 mL) and extracted with ethyl acetate (500 mL). The organics were dried over magnesium sulfate, filtered and evaporated in vacuo to afford crude product. The crude product was purified by flash silica chromatography with elution 30% ethyl acetate in isohexane. Pure fractions were evaporated to dryness to afford the sub-title product (98 g) as a red oil.

1. extractionextracted with ethyl acetate (500 mL)
2. dry with materialThe organics were dried over magnesium sulfate
3. filtrationfiltered
4. customevaporated in vacuo
5. customto afford crude product
6. customThe crude product was purified by flash silica chromatography with elution 30% ethyl acetate in isohexane
7. customPure fractions were evaporated to dryness