4-Chlorobenzoic Acid → HCID 71656517, compound

HRID 1506845Notes

Reaction equation

HRID 1506845 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.ClC1C=CC(C(O)=O)=CC=1.S(Cl)(Cl)=O.[CH2:25]([C:29]1[O:30][C:31]2[CH:37]=[CH:36][C:35]([NH:38][S:39]([CH3:42])(=[O:41])=[O:40])=[CH:34][C:32]=2[CH:33]=1)[CH2:26][CH2:27][CH3:28]>ClCCl>[CH2:25]([C:29]1[O:30][C:31]2[CH:37]=[CH:36][C:35]([NH:38][S:39]([CH3:42])(=[O:40])=[O:41])=[CH:34][C:32]=2[C:33]=1[C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH2:26][CH2:27][CH3:28]

Participants

6

Reactant 4

HCID 63184-Chlorobenzoic AcidHCID 85014-Chlorobenzoyl chlorideHCID 24386Thionyl ChlorideHCID 9878493N-(2-Butyl-1-benzofuran-5-yl)methanesulfonamide

Product 1

HCID 71656517HCID 71656517, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.02 g of 4-chlorobenzoyl chloride—prepared by reacting 4-chlorobenzoic acid with thionyl chloride—and 5.42 g of 2-butyl-5-methanesulfonamido-benzofuran (IV) were dissolved in 30 ml of dichloromethane. The reaction was performed according to Example 10.

Sources & evidence

ORD record
ord-55574ad9fca343b5ad1bda5bbe199ef6
Source dataset
uspto-grants-2015_12
Patent number
US09221777B2

Reaction notes

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