Pyridine → HCID 89907420, compound

HRID 1506851Notes

Reaction equation

HRID 1506851 reaction equation
FC(F)(F)C(OC(=O)C(F)(F)F)=O.[Cl:14][C:15]1[CH:16]=[CH:17][C:18]2[O:23][CH:22]([C:24]([NH2:26])=O)[O:21][C:20]([CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)([CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[C:19]=2[CH:39]=1.N1C=CC=CC=1>O1CCOCC1>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]2[O:23][CH:22]([C:24]#[N:26])[O:21][C:20]([CH:33]3[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]3)([CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[C:19]=2[CH:39]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 9845Trifluoroacetic anhydrideHCID 89907188HCID 89907188, compound

Product 1

HCID 89907420HCID 89907420, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

4.19 ml Trifluoroacetic anhydride is added dropwise to a solution of 3.25 g 6-chloro-4,4-dicyclohexyl-4H-benzo[1,3]dioxine-2-carboxylic amide and 1.7 ml pyridine in 29 ml dioxane at 0° C. The reaction was stirred for 30 min at 0° C. and for 4 h at room temperature. The reaction mixture was then poured on ice water and stirred for 30 min. The precipitate was filtered, washed with water and dried over P2O5 under vaccum. Yield: 2.95 g.

Workup

  1. additionThe reaction mixture was then poured on ice water
  2. stirringstirred for 30 min
  3. filtrationThe precipitate was filtered
  4. washwashed with water
  5. dry with materialdried over P2O5 under vaccum

Sources & evidence

ORD record
ord-5a2d5be55c7444eb816c604a3d0cca58
Source dataset
uspto-grants-2015_12
Patent number
US09221784B2

Reaction notes

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