Methanol → HCID 60155537, compound

HRID 1506880Notes

Reaction equation

HRID 1506880 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([F:11])=[CH:4][C:3]=1[CH:12]([CH3:16])[C:13]([OH:15])=[O:14].[CH3:17]O>Cl>[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([F:11])=[CH:4][C:3]=1[CH:12]([CH3:16])[C:13]([O:15][CH3:17])=[O:14]

Participants

4

Reactant 2

HCID 887MethanolHCID 60155536HCID 60155536, compound

Product 1

HCID 60155537HCID 60155537, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Compound (27a) (6.2 g, 26.8 mmol) was dissolved in a solution of a catalytic amount of concentrated hydrochloric acid (0.24 mL) in methanol (123 mL) and treated in the same manner as in (c) in Production Example 1 to give 5.9 g (90%) of compound (28a) as pale yellow oil.

Sources & evidence

ORD record
ord-b68596fc55e44fafbd6300a68e23fc99
Source dataset
uspto-grants-2015_12
Patent number
US09221786B2

Reaction notes

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