Methanol → HCID 117676157, compound

HRID 1506881Notes

Reaction equation

HRID 1506881 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[CH:12]([CH3:16])[C:13]([OH:15])=[O:14].[CH3:17]O>Cl>[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[CH:12]([CH3:16])[C:13]([O:15][CH3:17])=[O:14]

Participants

4

Reactant 2

HCID 887MethanolHCID 534295682-(2,6-Difluoro-4-nitrophenyl)propanoic acid

Product 1

HCID 117676157HCID 117676157, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Compound (27b) (3.6 g, 15.6 mmol) was dissolved in a solution of a catalytic amount of concentrated hydrochloric acid (0.14 mL) in methanol (72 mL) and treated in the same manner as in (c) in Production Example 1 to give 3.4 g (89%) of compound (28b) as pale yellow oil.

Sources & evidence

ORD record
ord-4f507540534e416d9131d48014a96221
Source dataset
uspto-grants-2015_12
Patent number
US09221786B2

Reaction notes

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