Hydrochloric Acid → HCID 54575276, compound

HRID 1506939Notes

Reaction equation

HRID 1506939 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([CH2:15][NH:16][C:17](=[O:28])[C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([NH2:25])=[CH:20][C:19]=3[O:26][CH3:27])[CH2:11][CH2:10]2)[CH:5]=[N:4][N:3]=[N:2]1.Cl>C(O)C>[ClH:24].[N:1]1([CH2:6][CH2:7][CH2:8][N:9]2[CH2:10][CH2:11][CH:12]([CH2:15][NH:16][C:17](=[O:28])[C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([NH2:25])=[CH:20][C:19]=3[O:26][CH3:27])[CH2:13][CH2:14]2)[CH:5]=[N:4][N:3]=[N:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54575166HCID 54575166, compound

Product 1

HCID 54575276HCID 54575276, compoundYield 147.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-((1-(3-(tetrazol-1-yl)propyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide (Example 2) (517 mg, 1.27 mmol) was dissolved in ethanol (10 mL) and a 12N hydrochloride solution (0.16 mL, 1.90 mmol) was added thereto. The reaction mixture was stirred at room temperature for 12 hours and then filtered to afford the title compound (417 mg, 74%).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-1d7a714d7af24e9d85f6b87e14422cfe
Source dataset
uspto-grants-2015_12
Patent number
US09221790B2

Reaction notes

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