3-Amino-1-propanol → HCID 90093058, compound

HRID 1507142Notes

Reaction equation

HRID 1507142 reaction equation
[CH:1]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1)=O.[NH2:14][CH2:15][CH2:16][CH2:17][OH:18]>>[OH:18][CH2:17][CH2:16][CH2:15][NH:14][CH2:1][C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 19600808Ethyl 2-formylpyridine-4-carboxylate

Product 1

HCID 90093058HCID 90093058, compound

Procedure

By General Procedure A from ethyl 2-formylpyridine-4-carboxylate and 3-aminopropan-1-ol. Purification by column chromatography (0-5% MeOH in DCM) gave the title compound. 1H NMR (300 MHz, CDCl3), δ ppm: 8.72 (d, 1H), 7.98 (s, 1H), 7.75 (d, 1H), 4.45 (q, 2H), 3.95 (s, 2H), 3.70 (t, 2H), 2.80 (t, 2H), 1.75 (m, 2H), 1.40 (t, 3H).

Workup

  1. customPurification by column chromatography (0-5% MeOH in DCM)

Sources & evidence

ORD record
ord-8b3290da2f41410ba1bd95d95a7c11dd
Source dataset
uspto-grants-2015_12
Patent number
US09221801B2

Reaction notes

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