2-Methoxybenzaldehyde → HCID 90094314, compound

HRID 1507146Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.[F:11][C:12]([F:39])([F:38])[C:13]([N:15]([CH2:26][C:27]1[CH:32]=[C:31]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH:30]=[CH:29][N:28]=1)[CH2:16][C:17](=[O:25])[NH:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:14]>>[F:38][C:12]([F:11])([F:39])[C:13]([N:15]([CH2:26][C:27]1[CH:32]=[C:31]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH:30]=[CH:29][N:28]=1)[CH2:16][C:17](=[O:25])[NH:18][CH:19]1[CH2:24][CH2:23][N:22]([CH2:5][C:4]2[CH:7]=[CH:8][CH:9]=[CH:10][C:3]=2[O:2][CH3:1])[CH2:21][CH2:20]1)=[O:14]

Participants

Reactant 2

HCID 86582-Methoxybenzaldehyde

HCID 90093924HCID 90093924, compound

Product 1

HCID 90094314HCID 90094314, compound

Procedure

Prepared by General Procedure A from 2-methoxybenzaldehyde and ethyl 2-[(2,2,2-trifluoro-N-{[(piperidin-4-yl)carbamoyl]methyl}acetamido)methyl]pyridine-4-carboxylate. 1H-NMR (300 MHz, CDCl3): δ 8.75 & 8.71 (2d, 1H; rotamer), 7.91-7.78 (m, 2H), 7.36 (m, 1H), 7.25 (m, 1H), 7.99-7.86 (m, 2H), 4.95 & 4.72 (2s, 2H, rotamer), 4.45 (q, 2H), 4.30 & 4.08 (2s, 2H; rotamer), 3.83 (m, 4H), 3.60 (m, 2H) 2.95 (m, 2H), 2.22 (m, 2H), 1.90 (m, 2H), 1.60 (m, 2H), 1.40 (t, 3H).

Sources & evidence

ORD record: ord-bb3b65c3cf1b4a97befbebbe9467af63
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221801B2

Reaction notes

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