Tetrahydrofuran → Tert-butyl 4-hydroxypiperidine-1-carboxylate

HRID 150737Notes

Reaction equation

HRID 150737 reaction equation
[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13]([O:14][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:15].[NH:1]1[CH2:2][CH2:3][CH:4]([OH:7])[CH2:5][CH2:6]1.[O:20]1[CH2:21][CH2:22][CH2:23][CH2:24]1>>[N:1]1([C:13]([O:12][C:8]([CH3:9])([CH3:10])[CH3:11])=[O:14])[CH2:2][CH2:3][CH:4]([OH:7])[CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 79341Piperidin-4-olHCID 10219638Carbonic acid, bis(1,1-dimethylethyl) ester

Product 1

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-8b1af4ba49df4fd0901e23c0ca74ee74
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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