Trifluoroacetic acid → HCID 56942175, compound

HRID 1507872Notes

Reaction equation

HRID 1507872 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:22][CH2:21][C@@H:20]([NH:23]C(=O)OC(C)(C)C)[CH2:19]2)[C:5]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[S:8][C:6]=2[N:7]=1.FC(F)(F)C(O)=O>ClCCl>[NH2:23][C@@H:20]1[CH2:21][CH2:22][N:18]([C:4]2[C:5]3[CH:10]=[C:9]([C:11]4[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=4)[S:8][C:6]=3[N:7]=[C:2]([NH2:1])[N:3]=2)[CH2:19]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66758218HCID 66758218, compound

Product 1

HCID 56942175HCID 56942175, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound of example 338 (66 mg, 0.15 mmol) in dichloromethane (6 ml) was added trifluoroacetic acid (3 ml). The solution was stirred at room temperature for 30 minutes. The solvents were evaporated in vacuo and co-evaporated with toluene. The residue was directly used for further reaction without any purification.

Workup

  1. customThe solvents were evaporated in vacuo and co-evaporated with toluene
  2. customThe residue was directly used for further reaction without any purification

Sources & evidence

ORD record
ord-145cce083d80427b999d8ca4ac790a8c
Source dataset
uspto-grants-2015_12
Patent number
US09221822B2

Reaction notes

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