Cyclopropylboronic acid → 4-cyclopropylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

HRID 1508228Notes

Reaction equation

HRID 1508228 reaction equation
[CH3:1][O:2][N:3]=[C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][C:11]=2[CH3:13])[O:6][CH2:5]1.[CH:14]1(B(O)O)C[CH2:15]1>>[CH3:1][O:2][N:3]=[C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][C:11]=2[CH:13]2[CH2:15][CH2:14]2)[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 2760897Cyclopropylboronic acidHCID 867219254-methylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

Product 1

HCID 867219274-cyclopropylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

Procedure

This compound was prepared using a method analogous to that of 4-methylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime (A.2.11.4), cyclopropylboronic acid replacing trimethylboroxine. Purification by CC using Hept/EtOAc (9/1 to 8/2) gives the desired product as white solid;

Workup

  1. customThis compound was prepared
  2. customPurification by CC

Sources & evidence

ORD record
ord-a7b15b5e71ed4be5a75468572d555b6c
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

Loading…