反应详情

温度

60 °C

To a solution of 2,4-dichloro-6-methylnicotinic acid ethyl ester (2.49 mmol) in 6 mL EtOH was added NaOEt (2.61 mmol). The reaction mixture was heated to 60° C. overnight in a closed vessel. At RT, the mixture was diluted with EtOAc and washed with aq. NH4Cl solution. The organic layer was dried over MgSO4 and concentrated in vacuo. Purification by (KP-SIL™ from Biotage) using Hept/EtOAc (1/1) gives the desired product as beige solid;

1. washwashed with aq. NH4Cl solution
2. dry with materialThe organic layer was dried over MgSO4
3. concentrationconcentrated in vacuo
4. customPurification by (KP-SIL™ from Biotage)