2-Chloroethyl methyl ether → HCID 12183844, compound

HRID 1508367Notes

Reaction equation

HRID 1508367 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:6][O:7][CH2:8][CH2:9]Cl>>[CH3:6][O:7][CH2:8][CH2:9][N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 123162-Chloroethyl methyl etherHCID 31268Pyrrolidine

Product 1

HCID 12183844HCID 12183844, compoundYield 70%

Procedure

Pyrrolidine (Wako Pure Chemical Industries, Ltd.), 1.51 parts by weight, and 2-methoxyethyl chloride (Kanto Chemical Co., Inc.), 1.00 part by weight, were mixed together and reacted for 1 hour under refluxing. Following the reaction, the reaction mixture was separated into two phases, then left to cool for a while, whereupon the bottom phase solidified. The top phase alone was collected by decantation, and purification was carried out by vacuum distillation. This distillation gave 0.96 part by weight of the target substance N-2-methoxyethylpyrrolidine (boiling point, 76° C.; vapor pressure, 45 mmHg) in a yield of 70%.

Workup

  1. customreacted for 1 hour
  2. temperatureunder refluxing
  3. customthe reaction
  4. customthe reaction mixture was separated into two phases
  5. waitleft
  6. temperatureto cool for a while, whereupon the bottom phase
  7. customThe top phase alone was collected by decantation, and purification
  8. distillationwas carried out by vacuum distillation
  9. distillationThis distillation

Sources & evidence

ORD record
ord-33333f8fe09a476dbc606ff4b9392db0
Source dataset
uspto-grants-2015_12
Patent number
US09221847B2

Reaction notes

Loading…