Hydrochloric Acid → 2-(1-(4-Bromophenyl)-3-oxocyclobutyl)isoindoline-1,3-dione

HRID 1509318Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([N:16]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]3=[O:26])[CH2:11][C:10](OC)([O:12]C)[CH2:9]2)=[CH:4][CH:3]=1.Cl>CC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([N:16]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]3=[O:26])[CH2:9][C:10](=[O:12])[CH2:11]2)=[CH:6][CH:7]=1

Participants

Conditions

Temperature: 50 °C

Procedure

A solution of 2-(1-(4-bromophenyl)-3,3-dimethoxycyclobutyl)isoindoline-1,3-dione (0.3 g, 0.72 mmol) in Acetone (30 ml) was added 6M HCl (3 ml) and the resulting solution was stirred at 50° C. for 2 h. The reaction mixture was concentrated to give product 0.26 g.).

Workup

concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record: ord-0ae7650db79a4e2ab1c04bf262978ba9
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221838B2

Reaction notes

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