4-Chloro-6,7-dimethoxyquinoline → HCID 24822603, compound

HRID 1509985Notes

Reaction equation

HRID 1509985 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5]2.Cl[C:16]1[C:25]2[C:20](=[CH:21][C:22]([O:28][CH3:29])=[C:23]([O:26][CH3:27])[CH:24]=2)[N:19]=[CH:18][CH:17]=1>>[CH3:27][O:26][C:23]1[CH:24]=[C:25]2[C:20](=[CH:21][C:22]=1[O:28][CH3:29])[N:19]=[CH:18][CH:17]=[C:16]2[O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 4596104-Chloro-6,7-dimethoxyquinolineHCID 54638006-Hydroxy-1-naphthoic acid

Product 1

HCID 24822603HCID 24822603, compoundYield 68.4%

Procedure

The title compound (1.95 g, 68% yield) was prepared as a brown solid from 6-hydroxy-1-naphthoic acid (1.43 g, 7.6 mmol) and 4-chloro-6,7-dimethoxyquinoline (2.04 g, 9.14 mmol) by an analogous procedure to that described in example 1. LC-MS (m/z) 376 (M+1).

Sources & evidence

ORD record
ord-d42c6c205d244f9f9e94ca22d7c428e0
Source dataset
uspto-grants-2012_07
Patent number
US08211901B2

Reaction notes

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