Trifluoroacetic acid → HCID 44160196, compound

HRID 1510062Notes

Reaction equation

HRID 1510062 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[O:31][C:32]2[CH:37]=[C:36]([F:38])[CH:35]=[CH:34][C:33]=2[CH3:39])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[C:40]([OH:46])([C:42]([F:45])([F:44])[F:43])=[O:41]>C(Cl)Cl>[F:38][C:36]1[CH:35]=[CH:34][C:33]([CH3:39])=[C:32]([CH:37]=1)[O:31][C:17]1[N:18]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:19]2[C:24]([C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15])=[CH:23][CH:22]=[CH:21][CH:20]=2.[F:43][C:42]([F:45])([F:44])[C:40]([OH:46])=[O:41].[F:38][C:36]1[CH:35]=[CH:34][C:33]([CH3:39])=[C:32]([CH:37]=1)[O:31][C:17]1[N:18]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:19]2[C:24]([C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15])=[CH:23][CH:22]=[CH:21][CH:20]=2

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66920434HCID 66920434, compound

Product 2

HCID 44160196HCID 44160196, compoundHCID 45257317HCID 45257317, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the compound of step 2 (23 mg, 43.4 μmol) in DCM (8 ml) and TFA (2 ml) was stirred at room temperature for 1 h. The solvents were evaporated and the resulting solid dissolved in MOH and water and lyophilized overnight. The title compound was obtained in the form of the [2-(5-fluoro-2-methyl-phenoxy)-1-phenyl-1H-indol-3-yl]-piperazin-1-yl-methanone trifluoroacetic acid salt as a white solid. Yield: 21.0 mg.

Workup

  1. customThe solvents were evaporated
  2. dissolutionthe resulting solid dissolved in MOH and water

Sources & evidence

ORD record
ord-a39f97a2652b45ce9fe933b09208ee8e
Source dataset
uspto-grants-2012_07
Patent number
US08211885B2

Reaction notes

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