反应详情

温度

60 °C

To a solution of methyl 3-hydroxybenzoate (10.0 g, 65.7 mmol) in DMF (100 mL) was added potassium carbonate (18.17 g, 131.4 mmol) and 2-chloroethyl-p-toluenesulfonate (15.7 g, 67.0 mmol). After stirring at 60° C. overnight the reaction mixture was poured into H2O, extracted with ethyl acetate (three times), dried over MgSO4 and concentrated under vacuum. Purification by silica gel chromatography (10% EtOAc/hexanes) afforded the desired product.

1. extractionextracted with ethyl acetate (three times)
2. dry with materialdried over MgSO4
3. concentrationconcentrated under vacuum
4. customPurification by silica gel chromatography (10% EtOAc/hexanes)