Hydrogen Peroxide → HCID 69230924, compound

HRID 1510211Notes

Reaction equation

HRID 1510211 reaction equation
[BH4-].[Na+].[C:3]([O:6][C@@H:7]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH2:8][N:9]1[CH2:14][CH2:13][C:12]([CH2:15][CH2:16][O:17][CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:11][CH2:10]1)(=[O:5])[CH3:4].[OH-:37].[Na+].OO>C(O)C.O.C1COCC1>[C:3]([O:6][C@@H:7]([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][O:17][CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:11]([OH:37])[CH2:10]1)(=[O:5])[CH3:4]

Participants

8

Reactant 4

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 69226506HCID 69226506, compound

Product 1

HCID 69230924HCID 69230924, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

With reference to FIG. 8, General procedure II was used. The quantities of the chemicals in order of addition are as follows: NaBH4 (0.0191 g, 0.505 mmol), THF (10 ml), BF3-ether complex (0.066 ml, 0.536 mmol), (S)-2-(4-(2-(benzhydryloxy)ethyl)-5,6-dihydropyridin-1(2H)-yl)-1-phenylethyl acetate 7b (0.115 g, 0.252 mmol), water (0.3 ml), ethanol (0.5 ml), 3N NaOH (0.2 ml) and 30% H2O2 (0.2 ml, 1.26 mmol).

Workup

  1. additionThe quantities of the chemicals in order of addition

Sources & evidence

ORD record
ord-49bcb81703b841769b60fbb1580cdb57
Source dataset
uspto-grants-2012_07
Patent number
US08211916B2

Reaction notes

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