反应详情

To a mixture of 2-anilino-N-[4-(4-pyridinyl)phenyl]acetamide (5.03 g) in tetrahydrofuran (100.6 ml) was added 1N hydrochloric acid (16.5 mL) at ambient temperature and stirred at ambient temperature for 1 hour. Tetrahydrofuran (300 mL) was added to the mixture and the mixture was cooled with ice bath stirring for 20 minutes. The crystals were collected by filtration and washed with ethyl acetate (50 mL) to afford 2-anilino-N-[4-(4-pyridinyl)phenyl]acetamide hydrochloride (5.00 g) as yellow crystals.

1. temperaturethe mixture was cooled with ice bath
2. stirringstirring for 20 minutes
3. filtrationThe crystals were collected by filtration
4. washwashed with ethyl acetate (50 mL)