反应详情

To a solution of 2-anilino-N-[4-(4-pyridinyl)phenyl]acetamide (50 mg) in N,N-dimethylformamide (1.0 mL) were added triethylamine (0.092 mL) and acetyl chloride (0.0352 mL) at ambient temperature and the mixture was stirred at ambient temperature overnight. Water (3 mL) was added to the mixture and the resulting mixture was extracted with ethyl acetate (5 mL). The organic layer was washed with brine and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was purified by preparative thin-layer chromatography (10% methanol in chloroform) to afford 2-[acetyl(phenyl)amino]-N-[4-(4-pyridinyl)phenyl]acetamide (46.9 mg) as a white amorphous.

1. extractionthe resulting mixture was extracted with ethyl acetate (5 mL)
2. washThe organic layer was washed with brine
3. dry with materialdried over magnesium sulfate
4. customThe solvent was evaporated in vacuo
5. customthe residue was purified by preparative thin-layer chromatography (10% methanol in chloroform)