Diethyl Ether → 4-amino-5-chloro-2-fluoro-N-(1-methyl-4-piperidyl)benzamide

HRID 151030Notes

Reaction equation

HRID 151030 reaction equation
[CH3:59][CH2:60][O:61][CH2:62][CH3:63].[CH:21]([N:22]([CH:23]([CH3:24])[CH3:25])[CH2:26][CH3:27])([CH3:28])[CH3:29].[NH2:13][CH:14]1[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]1.[NH2:1][c:2]1[cH:3][c:4]([F:12])[c:5]([C:6](=[O:7])[OH:8])[cH:9][c:10]1[Cl:11].[O:54]=[CH:55][N:56]([CH3:57])[CH3:58].[P-:30]([F:31])([F:32])([F:33])([F:34])([F:35])[F:36].[n:37]1([O:38][C:39]([N:40]([CH3:41])[CH3:42])=[N+:43]([CH3:44])[CH3:45])[c:46]2[n:47][cH:48][cH:49][cH:50][c:51]2[n:52][n:53]1>>[NH2:1][c:2]1[cH:3][c:4]([F:12])[c:5]([C:6](=[O:8])[NH:13][CH:14]2[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]2)[cH:9][c:10]1[Cl:11]

Participants

8

Reactant 7

HCID 3283Diethyl EtherHCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 27375314-Amino-1-methylpiperidineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 686839334-Amino-5-chloro-2-fluorobenzoic acid

Product 1

HCID 686824664-amino-5-chloro-2-fluoro-N-(1-methyl-4-piperidyl)benzamide

Sources & evidence

ORD record
ord-e2fc0b0c9d714b9ab1f77377e7fe4bad
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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