Hydrochloric Acid → HCID 59335126, compound

HRID 1510325Notes

Reaction equation

HRID 1510325 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17]([C:22]([O:24]CC)=[O:23])=[CH:16]3)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+].Cl>O1CCCC1.O>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17]([C:22]([OH:24])=[O:23])=[CH:16]3)(=[O:10])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59335063HCID 59335063, compound

Product 1

HCID 59335126HCID 59335126, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×

Procedure

100 mg ethyl 5-(3,5-dichloro-phenylsulphonylamino)-1H-indole-2-carboxylate are dissolved in 2 ml of tetrahydrofuran, combined with 2 ml 1 N sodium hydroxide solution and stirred for 48 hours at ambient temperature. Then the tetrahydrofuran is eliminated in vacuo, diluted with some water and combined with 2 ml of 2 N hydrochloric acid. The solid is suction filtered, washed with water and dried in vacuo.

Workup

  1. filtrationfiltered
  2. washwashed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-11ac906991154e35bcb7257489ad02b5
Source dataset
uspto-grants-2012_07
Patent number
US08211923B2

Reaction notes

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