Trifluoroacetic acid → (R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid

HRID 15104Notes

Reaction equation

HRID 15104 reaction equation

[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C@H:10]([CH3:18])[C:11]([O:13]C(C)(C)C)=[O:12])=[O:8])=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>ClCCl>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C@H:10]([CH3:18])[C:11]([OH:13])=[O:12])=[O:8])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 68637194tert.-butyl(R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate

Product 1

HCID 68637698(R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 2e from tert.-butyl(R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate with TFA in dichloromethane.

Sources & evidence

ORD record: ord-5eda29662cb946f2bc1e4c611605929e
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732466B2

Reaction notes

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