Hydrochloric Acid → HCID 86660104, compound

HRID 1510924Notes

Reaction equation

HRID 1510924 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[C-:12]#[N:13].[K+].Cl>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[N:9]([C:12]#[N:13])[CH:10]=[S:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 9032Potassium CyanideHCID 810662,4-Dichloro-1-isothiocyanatobenzene

Product 1

HCID 86660104HCID 86660104, compoundYield 97.9%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

40 ml of acetonitrile solution containing 6.44 g of 2,4-dichlorophenyl isothiocyanate was added dropwise to 40 ml of aqueous solution containing 2.28 g of potassium cyanide at 0° C. over 1 hour. After 3 hours of reaction at room temperature, the reaction solution was poured into a mixed solution of 50 ml of 1N hydrochloric acid and ice. Deposited crystals were separated by filtration and were dried under reduced pressure to obtain 7.14 g of N-(2,4-dichlorophenyl)cyanothioformamide (yield: 97%).

Workup

  1. customAfter 3 hours of reaction at room temperature
  2. customDeposited crystals were separated by filtration
  3. customwere dried under reduced pressure

Sources & evidence

ORD record
ord-b7b65d41c42d4215b68075040684e547
Source dataset
uspto-grants-2012_07
Patent number
US08212050B2

Reaction notes

Loading…