Hydrochloric Acid → 2-Fluoro-2-(quinolin-6-yl)acetic acid

HRID 1511337노트

반응식

HRID 1511337 반응식
[F:1][CH:2]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)[C:3]([O:5]C)=[O:4].[OH-].[Na+].Cl>CO>[F:1][CH:2]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)[C:3]([OH:5])=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57691374Methyl 2-fluoro-2-(quinolin-6-yl)acetate

생성물 1

HCID 576909192-Fluoro-2-(quinolin-6-yl)acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution containing methyl 2-fluoro-2-(quinolin-6-yl)acetate (0.49 g, 2.2 mmol) in methanol (3.0 ml) was added sodium hydroxide (5 M, 1.0 ml, 5.0 mmol). The mixture was stirred at rt for 48 h and then neutralized with 5 N HCl (1.0 mL). The solution was allowed to sit overnight during which time a precipitate formed. The solution was filtered and the filtercake washed with cold water then dried under vacuum to afford the title compound as a tan solid. MS (ESI, pos. ion) m/z: 206 (M+1).

후처리

  1. waitto sit overnight during which time
  2. customa precipitate formed
  3. filtrationThe solution was filtered
  4. washthe filtercake washed with cold water
  5. customthen dried under vacuum

출처 및 근거

ORD 기록
ord-891fd018781f48bca27cb92c6fc5001f
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08212041B2

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