Acetate → 1-[(3,5-dichloropyridin-4-yl)methyl]-6-methoxy-4-phenylphthalazine

HRID 151171Notes

Reaction equation

HRID 151171 reaction equation
[Br:8][c:9]1[n:10][n:11][c:12]([CH2:21][c:22]2[c:23]([Cl:29])[cH:24][n:25][cH:26][c:27]2[Cl:28])[c:13]2[cH:14][cH:15][c:16]([O:19][CH3:20])[cH:17][c:18]12.[C:54]([O-:55])(=[O:56])[CH3:57].[C:59]([O-:60])(=[O:61])[CH3:62].[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[Pd+2:58].[c:1]1([Li:7])[cH:2][cH:3][cH:4][cH:5][cH:6]1.[c:30]1([P:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[cH:44][cH:45][cH:46][cH:47][cH:48]1>>[c:1]1(-[c:9]2[n:10][n:11][c:12]([CH2:21][c:22]3[c:23]([Cl:29])[cH:24][n:25][cH:26][c:27]3[Cl:28])[c:13]3[cH:14][cH:15][c:16]([O:19][CH3:20])[cH:17][c:18]23)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 9908871HCID 9908871, compoundHCID 178506676HCID 178506676, compound

Product 1

HCID 99525921-[(3,5-dichloropyridin-4-yl)methyl]-6-methoxy-4-phenylphthalazine

Sources & evidence

ORD record
ord-08db4357ac4a474da711af5f96161bdc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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