1-Chloro-4-(chloromethyl)benzene → (4-Chloro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester

HRID 1511939노트

반응식

HRID 1511939 반응식
[C:1]([O:5][C:6](=[O:13])[NH:7][N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:3])[CH3:2].[Cl:14][C:15]1[CH:22]=[CH:21][C:18]([CH2:19]Cl)=[CH:17][CH:16]=1.[H-].[Na+]>>[C:1]([O:5][C:6](=[O:13])[N:7]([CH2:19][C:18]1[CH:21]=[CH:22][C:15]([Cl:14])=[CH:16][CH:17]=1)[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 3

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 24758Sodium hydrideHCID 49760548tert-Butyl 1H-pyrrol-1-ylcarbamate

생성물 1

HCID 67230228(4-Chloro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester

실험 절차

Prepared according to the benzylation condition used in Example 1 step b) from pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.), 4-chlorobenzyl chloride (1.03 eq.) and sodium hydride (1.3 eq.). ESI (m/z): 307 (M+H)+.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-8c743ffeb478420aae07b1db09bc24fe
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217043B2

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