Sodium Hydroxide → HCID 67231385, compound

HRID 1511967Notes

Reaction equation

HRID 1511967 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2].[Cl-].[NH4+:17].[OH-].[Na+].[OH-].[NH4+].[O-]Cl.[Na+]>CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)C.[Cl-]>[CH2:1]([O:3][C:4]([C:6]1[N:7]([NH2:17])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

Participants

7

Reactant 5

HCID 14798Sodium HydroxideHCID 14923Ammonium HydroxideHCID 25517Ammonium ChlorideHCID 2727899ethyl 5-fluoro-1H-indole-2-carboxylateHCID 23665760Sodium Hypochlorite

Product 1

HCID 67231385HCID 67231385, compound

Reagents, catalysts & solvents 1

HCID 21218Trioctylmethylammonium chlorideCatalyst

Procedure

Prepared according to the N-amination condition used in Example 18 step a) from 5-fluoro-1H-indole-2-carboxylic acid ethyl ester (prepared according to literature: J. Chem. Soc. 1955, 1283-1284), ammonium chloride, ALIQUAT 336, sodium hydroxide, concentrated ammonium hydroxide solution and 10% solution of NaOCl. ESI (m/z): 223 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1b7c05d529174d038c961f59b0b70d0f
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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