反应详情

温度

120 °C

2-Fluoroethyl bromide was added to a mixture of 2,2-dimethyl-propionic acid 7-(2-chloro-3,6-difluoro-phenyl)-6-oxo-5,6-dihydro-pyrido[2,3-b]pyrazin-8-yl ester (Example 1.3) (0.20 g), potassium carbonate (0.207 g) and potassium iodide (catalytic amount) in N,N-dimethylformamide (10 ml). The reaction mixture was heated in the microwave for 20 minutes at 120° C. The reaction mixture was concentrated and the residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane 1:1) to give Compound No. C9 of Table C as a yellow solid (0.103 g).

1. concentrationThe reaction mixture was concentrated
2. customthe residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane 1:1)
3. customto give Compound No