Pyrrolidine → HCID 68582180, compound

HRID 1512342Notes

Reaction equation

HRID 1512342 reaction equation
[F:1][C:2]1[N:9]=[C:8](F)[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>>[F:1][C:2]1[N:9]=[C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 404271652,5,6-Trifluoronicotinonitrile

Product 1

HCID 68582180HCID 68582180, compoundYield 57%

Procedure

Prepared in 57% yield from 2,5,6-Trifluoro-nicotinonitrile and pyrrolidine according to the procedure described for Example 178A. 1H NMR (DMSO-d6) δ 1.85-1.93 (m, 4H), 3.55-3.62 (m, 4H), 8.01 (dd, J=12.2, 6.8 Hz, 1H).

Sources & evidence

ORD record
ord-c404ab77effb4f799d647e2deeebc943
Source dataset
uspto-grants-2012_07
Patent number
US08217067B2

Reaction notes

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