Hydrochloric Acid → HCID 44547022, compound

HRID 1512941Notes

Reaction equation

[OH-].[Na+].[CH3:3][CH:4]([O:6][C:7]1[N:12]=[CH:11][C:10]([C:13]2[O:17][N:16]=[C:15]([C:18]3[CH:26]=[C:25]4[C:21]([C:22]([CH2:27][CH2:28][C:29]([O-:31])=[O:30])=[CH:23][NH:24]4)=[CH:20][CH:19]=3)[N:14]=2)=[CH:9][C:8]=1[O:32][CH3:33])[CH3:5].Cl>C1COCC1.O>[CH3:5][CH:4]([O:6][C:7]1[N:12]=[CH:11][C:10]([C:13]2[O:17][N:16]=[C:15]([C:18]3[CH:26]=[C:25]4[C:21]([C:22]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[CH:23][NH:24]4)=[CH:20][CH:19]=3)[N:14]=2)=[CH:9][C:8]=1[O:32][CH3:33])[CH3:3]

Participants

Conditions

Temperature: 90 °C

Procedure

Sodium hydroxide (50 mg) was added to a solution of 3-(6-{5-[6-[(1-methylethyl)oxy]-5-(methyloxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoate (D112) (258 mg) in THF (3 mL) and water (3 mL). The resulting mixture was heated at 90° C. for 1 hour. Then 0.5 M HCl solution was added until pH was about 6. The solvent was concentrated, and the residue was dissolved in water. The precipitated solid was purified by Mass Directed Auto Prep to afford 3-(6-{5-[6-[(1-methylethyl)oxy]-5-(methyloxy)-3-pyridinyl]-1,2,4-oxadiazol-3-yl}-1H-indol-3-yl)propanoic acid (E87) (158 mg) as a white solid. δH (DMSO-d6, 400 MHz): 1.35 (6H, d), 2.61 (2H, t), 2.97 (2H, t), 3.94 (3H, s), 5.42 (1H, m), 7.34 (1H, d), 7.72 (2H, m), 7.82 (1H, d), 8.13 (1H, s), 8.54 (1H, d), 11.18 (1H, s), 12.08 (1H, br s). MS (ES): C22H22N4O5 requires 422; found 423.2.

Workup

concentrationThe solvent was concentrated
dissolutionthe residue was dissolved in water
customThe precipitated solid was purified by Mass Directed Auto Prep

Sources & evidence

ORD record: ord-f119712219f54e76aac0704523543f50
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217028B2

Reaction notes

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