Water → HCID 68513296, compound

HRID 1513007Notes

Reaction equation

HRID 1513007 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([OH:11])=[C:4]([O:12][CH3:13])[CH:3]=1.[F:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[C:16]=1[CH2:17]Br.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([O:11][CH2:17][C:16]2[C:19]([O:23][CH3:24])=[CH:20][CH:21]=[CH:22][C:15]=2[F:14])=[C:4]([O:12][CH3:13])[CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 27793222-Fluoro-6-methoxybenzyl bromideHCID 59310043HCID 59310043, compound

Product 1

HCID 68513296HCID 68513296, compoundYield 94.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-chloro-2-methoxy-5-nitrophenol (0.67 g) and 2-fluoro-6-methoxy-benzyl bromide (0.66 g) in N,N-dimethylformamide (3 mL) was added potassium carbonate (0.54 g), and the mixture was stirred at room temperature for 3 days. The reaction mixture was poured into water, and the resulting mixture was stirred at room temperature for 30 minutes. The precipitated crystals were collected by filtration. The collected crystals were washed with water and a mixed solvent (diethyl ether/n-hexane=1/3), and dried under reduced pressure to give 5-chloro-2-(2-fluoro-6-methoxybenzyloxy)-4-nitroanisole (0.97 g). This material was dissolved in tetrahydrofuran (15 mL). To the solution were added methanol (15 mL) and nickel(II) bromide (31 mg). To the mixture was added sodium borohydride (0.32 g) under ice-cooling, and the mixture was stirred at the same temperature for 30 minutes, and then stirred at room temperature for 30 minutes. The reaction mixture was poured into a saturated aqueous sodium hydrogen carbonate solution, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=4/1−3/2) to give the title compound (0.79 g).

Workup

  1. stirringthe resulting mixture was stirred at room temperature for 30 minutes
  2. filtrationThe precipitated crystals were collected by filtration
  3. washThe collected crystals were washed with water
  4. dry with materiala mixed solvent (diethyl ether/n-hexane=1/3), and dried under reduced pressure

Sources & evidence

ORD record
ord-bc367ce92a404d689320ecf3b185dadc
Source dataset
uspto-grants-2012_07
Patent number
US08217069B2

Reaction notes

Loading…