Hydrochloric Acid → HCID 86645644, compound

HRID 1513330Notes

Reaction equation

HRID 1513330 reaction equation
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[C:11](=[O:12])[N:10]([C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:14])[C:9](=[O:21])[C:8]([CH3:22])=[N:7]1.Cl>O1CCCC1>[CH3:22][C:8]1[C:9](=[O:21])[N:10]([C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:14])[C:11](=[O:12])[N:6]([CH2:5][CH2:4][CH:3]=[O:2])[N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59496107HCID 59496107, compound

Product 1

HCID 86645644HCID 86645644, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-[3,3-bis(methyloxy)propyl]-6-methyl-4-(phenylcarbonyl)-1,2,4-triazine-3,5(2H,4H)-dione (P3, 92 mg, 0.276 mmol) in Tetrahydrofuran (THF) (2.3 mL), 1N hydrochloric acid aqueous solution (0.690 mL, 0.690 mmol) was added and the mixture was stirred at rt for 2.5 hours. The reaction was then quenched with water and extracted with AcOEt. Organic phase was washed with water and NaHCO3 saturated solution, dried over Na2SO4 and evaporated under reduced pressure affording 3-[6-methyl-3,5-dioxo-4-(phenylcarbonyl)-4,5-dihydro-1,2,4-triazin-2(3H)-yl]propanal as a crude product that was used for next step without purification.

Workup

  1. customThe reaction was then quenched with water
  2. extractionextracted with AcOEt
  3. washOrganic phase was washed with water and NaHCO3 saturated solution
  4. dry with materialdried over Na2SO4
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-10c78cc6e4324c7a9dff3fb9cde6ecec
Source dataset
uspto-grants-2012_07
Patent number
US08217168B2

Reaction notes

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