Hydrochloric Acid → HCID 68433547, compound

HRID 1513344Notes

Reaction equation

HRID 1513344 reaction equation
[CH3:1][C:2]1[C:3](=[O:28])[NH:4][C:5](=[O:27])[N:6]([CH2:8][CH2:9][CH2:10][N:11]2[CH2:16][C@H:15]3[C@:13]([C:17]4[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=4)([CH2:14]3)[CH2:12]2)[N:7]=1.[ClH:29]>CCOCC>[ClH:29].[CH3:1][C:2]1[C:3](=[O:28])[NH:4][C:5](=[O:27])[N:6]([CH2:8][CH2:9][CH2:10][N:11]2[CH2:16][C@H:15]3[C@:13]([C:17]4[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=4)([CH2:14]3)[CH2:12]2)[N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25222719HCID 25222719, compound

Product 1

HCID 68433547HCID 68433547, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

6-methyl-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione was dissolved in Et2O and treated with HCl 1N in Et2O to form the title compound 6-methyl-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione hydrochloride salt (E2, 73.8 mg, 0.171 mmol).

Sources & evidence

ORD record
ord-ba943f30762c412086ce25e3523a34dd
Source dataset
uspto-grants-2012_07
Patent number
US08217168B2

Reaction notes

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