Trifluoroacetic acid → HCID 44546613, compound

HRID 1513464Notes

Reaction equation

HRID 1513464 reaction equation
[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([N:15]3[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]3)[N:12]=[C:11]([C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]4[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=4)=[O:30])=[CH:24][CH:23]=3)[N:10]=1)[CH2:2]2.C(O)(C(F)(F)F)=O.[CH2:45]1[N:50]([CH2:51][CH2:52][NH2:53])[CH2:49][CH2:48][O:47][CH2:46]1>>[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([N:15]3[CH2:16][CH2:17][CH:18]([NH:53][CH2:52][CH2:51][N:50]4[CH2:49][CH2:48][O:47][CH2:46][CH2:45]4)[CH2:19][CH2:20]3)[N:12]=[C:11]([C:22]3[CH:23]=[CH:24][C:25]([NH:28][C:29]([NH:31][C:32]4[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=4)=[O:30])=[CH:26][CH:27]=3)[N:10]=1)[CH2:2]2

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 4082852-MorpholinoethylamineHCID 44548798HCID 44548798, compound

Product 1

HCID 44546613HCID 44546613, compound

Procedure

Starting from 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-oxopiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea.TFA (50 mg)and 1-(2-aminoethyl)morpholine (0.031 mL) and following the procedure as outlined in example 118, the titled compound was isolated as its tri-TFA salt after HPLC purification; MS (ES+) 615.9 (M+H)+

Sources & evidence

ORD record
ord-c614c30f27fe47bdb8eea15818d3da75
Source dataset
uspto-grants-2012_07
Patent number
US08217036B2

Reaction notes

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