Trifluoroacetic acid → HCID 44546614, compound

HRID 1513465Notes

Reaction equation

HRID 1513465 reaction equation
[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([N:15]3[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]3)[N:12]=[C:11]([C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]4[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=4)=[O:30])=[CH:24][CH:23]=3)[N:10]=1)[CH2:2]2.C(O)(C(F)(F)F)=O.Cl.[CH3:46][O:47][C:48](=[O:51])[CH2:49][NH2:50]>C(N(CC)CC)C>[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:10]=[C:11]([C:22]3[CH:23]=[CH:24][C:25]([NH:28][C:29]([NH:31][C:32]4[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=4)=[O:30])=[CH:26][CH:27]=3)[N:12]=[C:13]([N:15]3[CH2:16][CH2:17][CH:18]([NH:50][CH2:49][C:48]([O:47][CH3:46])=[O:51])[CH2:19][CH2:20]3)[N:14]=1)[CH2:2]2

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 122755Glycine methyl ester hydrochlorideHCID 44548798HCID 44548798, compound

Product 1

HCID 44546614HCID 44546614, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineCatalyst

Procedure

Starting from 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-oxopiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea.TFA (50 mg) and glycine methyl ester hydrochloride (20 mg) and triethylamine (10 drops) and following the procedure as outlined in example 118 the title compound was isolated as its di-TFA salt after HPLC purification; MS (ES+) 574.8 (M+H)+.

Sources & evidence

ORD record
ord-c639fead11d743b89cdd559ceeb9f117
Source dataset
uspto-grants-2012_07
Patent number
US08217036B2

Reaction notes

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