反应详情

Dissolve [4-(2-azepan-1-yl-ethoxy)-phenyl]-[2-(2,5-difluorophenyl)-6-hydroxynaphthalen-1-yl]-methanone (770 mg, 1.54 mmol) in 10 mL THF and add 5.0 mL (5.0 mmol) of lithium triethylborohydride (1.0 M solution in THF). After one hour at room temp, add another 4.0 mL of the lithium triethylborohydride gently warm the solution with a heat gun. After ½ hour the reaction is complete. Quench the reaction with water and pour into a two phase system of saturated sodium bicarbonate and a 3/1 mixture of chloroform/isopropanol. Separate the phases, dry the organic layer with 3 Å sieves and evaporate to give the title compound to be taken on to the next step without purification.

1. temperaturegently warm the solution with a heat gun
2. waitAfter ½ hour the reaction is complete
3. customQuench
4. customthe reaction with water
5. customSeparate the phases
6. customdry the organic layer with 3 Å sieves
7. customevaporate