反应详情

A suspension of N-cyclooctyl-2-{3-[4-(2-methoxyphenyl)piperazino]propanoyl}-1-hydrazinecarboxamide D3 (0.40 g, 0.93 mmol) in 2M NaOH aqueous solution (10 mL) was heated at reflux for 18 hrs. The solution was cooled to room temperature and the pH was adjusted to 8 by the drop-wise addition of HCl 28%. The resulting precipitate was filtered to afford a white solid, which was twice boiled with ethyl acetate and filtered while hot. The filtrates were combined and evaporated under reduced pressure to afford 0.18 g (47%) 4-cyclooctyl-5-{2-[4-(2-methoxyphenyl)piperazino]ethyl}-2,4-dihydro-3H-1,2,4-triazol-3-one E10.

1. temperaturewas heated
2. temperatureat reflux for 18 hrs
3. filtrationThe resulting precipitate was filtered
4. customto afford a white solid, which
5. filtrationfiltered while hot
6. customevaporated under reduced pressure