Hydrochloric Acid → HCID 86640063, compound

HRID 1514448Notes

Reaction equation

HRID 1514448 reaction equation
[F:1][C:2]1([F:38])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11]3[CH:16]=[CH:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]4[CH2:26][C@H:25]5[C@:23]([C:27]6[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=6)([CH2:24]5)[CH2:22]4)[C:13](=[O:37])[N:12]=3)[C:4]=2[O:3]1.[ClH:39].O1CCOCC1>>[ClH:39].[F:38][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11]3[CH:16]=[CH:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]4[CH2:26][C@H:25]5[C@:23]([C:27]6[CH:28]=[CH:29][C:30]([C:33]([F:34])([F:35])[F:36])=[CH:31][CH:32]=6)([CH2:24]5)[CH2:22]4)[C:13](=[O:37])[N:12]=3)[C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 24752776HCID 24752776, compound

Product 1

HCID 86640063HCID 86640063, compound

Procedure

4-(2,2-Difluoro-1,3-benzodioxol-4-yl)-1-{4-[(1S,5R)-1-(4-trifluoromethyl-phenyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-butyl}-1H-pyrimidin-2-one was treated with 4N HCl in dioxane (1 eq), to give the title compound.

Sources & evidence

ORD record
ord-ca32ee66a0f54df39bbf2389a8d5b218
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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