反应详情

温度

85 °C

To a solution of 2-(2,6-dichloro-phenyl)-benzooxazole-6-carboxylic acid (8.9 mg) in anhydrous DMF (0.5 mL) was added BOP (17.4 mg), diisopropylethylamine (0.014 mL), and 2-o-tolyl-ethylamine (5.5 mg). The reaction mixture was stirred at 85° C. overnight, quenched with 1N NaOH aqueous solution at 0° C., extracted with EtOAc. The extracts were dried over Na2SO4 and concentrated in vacuo. The crude reaction mixture was purified by silica SPE eluting with EtOAc/Hexane to give 2-(2,6-dichlorophenyl)-benzooxazole-6-carboxylic acid (2-o-tolyl-ethyl)-amide: MS (m/z) 425.1 (M+1).

1. customquenched with 1N NaOH aqueous solution at 0° C.
2. extractionextracted with EtOAc
3. dry with materialThe extracts were dried over Na2SO4
4. concentrationconcentrated in vacuo
5. customThe crude reaction mixture
6. customwas purified by silica SPE
7. washeluting with EtOAc/Hexane